- 期刊Journal of ethnopharmacology（J Ethnopharmacol）
- 发表时间2026-10-12
- 作者Tang X, Li C
- 卷期页码122512
- 文献类型Review
- DOI10.1016/j.jep.2026.122512
- PMID42863729
摘要机译
[ETHNOPHARMACOLOGICAL相关性]由于具有多靶点协同和整体调节的独特优势，中医药在增强男性生殖功能方面显示出广阔的临床应用前景。《前进方》和《本草纲目》记录了五指延宗丸、肉豆蔻、蒲公英和淫羊癫一千多年来在男性生殖健康保护中的应用。
【本综述目的】本文系统综述了中药中活性成分（包括黄酮类、多酚类、萜类、生物碱和多糖）及相关配方在改善男性生殖损伤方面的应用研究进展，这些化合物通过调节多种信号通路改善男性生育能力。
并对该领域未来的研究方向和潜在应用进行了综述，旨在为中医药临床治疗男性生殖健康和开发新的治疗干预措施奠定理论基础。
[材料与方法]从Web of Science、Science Direct、PubMed等多个数据库检索有关中药有效成分及相关配方改善男性生殖损伤的相关文献。结果：
中药活性成分（如淫羊羚苷、金丝桃素、槲皮素）及其复方制剂（如桂露二仙焦、五子岩宗丸）可通过调节核心病理级联——包括氧化应激、炎症、凋亡、内分泌紊乱——并恢复正常生精所必需的生理微环境，改善男性生殖损伤。
[结论]通过大量的实验研究了有效成分和中药配方对改善男性生殖功能障碍的影响，揭示了中药具有通过多层次、多靶点机制对抗男性生殖功能障碍的潜力。然而，缺乏针对男性生殖功能障碍原因和相关治疗方法的综述。
因此，本综述旨在总结目前中医药对抗男性生殖功能障碍的研究进展，从而为未来临床前验证和临床应用治疗男性生殖功能障碍提供理论基础。
展开英文摘要原文
【ETHNOPHARMACOLOGICAL RELEVANCE】Due to their unique advantages of multi-target synergy and holistic regulation, traditional Chinese medicines (TCM) show promising clinical applications in enhancing male reproductive function. The 'Qianjin Fang' and 'Compendium of Materia Medica' document the use of Wuzhi Yanzong Wan, Cistanche, Cuscuta, and Epimedium for over a thousand years in the preservation of male reproductive health.
【AIM OF THIS REVIEW】This article provides a systematic review of research progress on the use of active components in TCM (including flavonoids, polyphenols, terpenoids, alkaloids, and polysaccharides) and related formulas in improving male reproductive damage. These compounds improve male fertility by regulating multiple signaling pathways. Furthermore, this review outlines future research directions and potential applications in this field, aiming to lay a theoretical foundation for the clinical treatment of male reproductive health using TCM and the development of novel therapeutic interventions.
【MATERIALS AND METHODS】The relevant literature on the effects of active ingredients in TCM and related formulas on improving male reproductive damage was retrieved from multiple databases, including Web of Science, ScienceDirect, PubMed, etc. RESULTS: Active components of TCM (such as icariin, hypericin, and quercetin) and their compound formulations (such as Guilu Erxian Jiao and Wuziyan Zongwan) can improve male reproductive damage by modulating core pathological cascades-including oxidative stress, inflammation, apoptosis, and endocrine disruption-and restoring the physiological microenvironment essential for normal spermatogenesis.
【CONCLUSION】Extensive experiments have been performed to investigate the effects of active ingredients and herbal formulas on improving male reproductive dysfunction, revealing that TCM has the potential to combat male reproductive dysfunction through multi-level, multi-target mechanisms. However, there is a lack of reviews addressing the causes of male reproductive dysfunction and related treatment approaches. Therefore, this review aims to summarize current research progress in the use of TCM to combat male reproductive dysfunction, thereby providing a theoretical foundation for future preclinical validation and clinical application in the treatment of male reproductive dysfunction.
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