- 期刊Journal of agricultural and food chemistry（J Agric Food Chem）
- 发表时间2026-08-26
- 作者Zhao KH, Han R, Lv BY, Zhang YJ, Sheikho A, Zhu YT, Shi QQ, Gao YQ, Gao JM
- 卷期页码V74(33) : 26311-26331
- DOI10.1021/acs.jafc.6c06602
- PMID42677629
摘要机译
对我国同源食用药用植物平坦黄芪（SAC）的种子进行了研究，得到了29个化合物，包括4个新的萜类化合物，星形类固醇A-D（1,2,6,23）和1个新的赤柱烷类固醇，星形类固醇（12）。利用核磁共振、HRESIMS、量子化学电子探针、核磁共振计算和x射线结晶学进行了结构澄清。
Astranlike A（1）具有新型5/6/6/6/5五环骨架，具有顺式融合的A/B环。评估了所有分离株在LPS刺激的BV-2细胞中的一氧化氮抑制作用。7-氧代β-谷甾醇（11）表现出强大的antineuroinflammatory活性，IC50为6.09±0.49μM。
该化合物抑制促炎细胞因子、NF-κB易位和iNOS/COX-2表达，激活HT22细胞中的Nrf2/HO-1，并保护神经元免受Aβ诱导的炎症损伤。在APP/PS1小鼠中，化合物11剂量依赖性地改善认知功能，减少Aβ斑块，减轻胶质炎症，支持其有前途的神经保护潜力。
展开英文摘要原文
An investigation of the seeds of Astragalus complanatus (SAC), a homologous food-medicine plant in China, yielded 29 compounds, including four new terpenoids, astranoids A-D (1, 2, 6, 23), and one new stigmastane steroid, astrasteroid (12). Structural elucidation was achieved using NMR, HRESIMS, quantum-chemical ECD, and NMR computations, and X-ray crystallography. Astranoid A (1) features a novel 5/6/6/6/5 pentacyclic skeleton with cis-fused A/B rings. All isolates were evaluated for nitric oxide inhibition in LPS-stimulated BV-2 cells. 7-oxo-β-sitosterol (11) demonstrated potent antineuroinflammatory activity with an IC50 of 6.09 ± 0.49 μM. This compound suppressed proinflammatory cytokines, NF-κB translocation, and iNOS/COX-2 expression, activated Nrf2/HO-1 in HT22 cells, and protected neurons from Aβ-induced inflammatory injury. In APP/PS1 mice, compound 11 dose-dependently improved cognitive function, reduced Aβ plaques, and attenuated glial inflammation, supporting its promising neuroprotective potential.
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