- 期刊Archives of medical research（Arch Med Res）
- 发表时间2026-09-28
- 作者Bergantini LS, Hartmann EM, Soares ÁAF, Sabino VLR, de Almeida FLA, Mais LN, Iser-Bem PN, Gorjão R, Curi R, Mathias PCF, Garcia RF
- 卷期页码V58(1) : 103525
- DOI10.1016/j.arcmed.2026.103525
- PMID42805151
摘要机译
[背景]关键发育时期的挑战，如产后过度喂养，会影响生物体的发育并增加其成年后对代谢综合征的易感性。这一阶段的营养或药物干预可能会缓解这种情况。
[目的]鉴于枸杞具有广泛的治疗特性，我们旨在评估用枸杞补充哺乳雌性大鼠的饮食是否可以防止在小窝中饲养的成年后代的代谢紊乱的发展。[方法]使用怀孕的Wistar大鼠制备窝产仔。出生后两天，雄性大鼠分为三组：正常窝产仔（NL），有9只幼崽；小窝产仔（SL），有3只幼崽；
和一窝三只幼崽，它们的母亲在哺乳期每天补充250毫克/千克枸杞提取物（SLGB）。所有动物出生后监测13周。[结果]哺乳期母亲补充枸杞提取物可显著降低体重增加、血脂异常、动脉粥样硬化指数和肥胖指数。
它还改善了胰岛素抵抗和葡萄糖不耐受，对骨骼肌产生了可能的肥大效应，并增加了成年后代中解偶联蛋白1（UCP-1）的表达。[结论]母亲补充枸杞提取物具有持久的效果，并防止了早期过度喂养的成年后代代谢综合征的发展。
展开英文摘要原文
【BACKGROUND】Challenges during critical developmental periods, such as postnatal overfeeding, can affect an organism's development and increase its susceptibility to metabolic syndrome in adulthood. Nutritional or pharmacological interventions during this stage may mitigate this condition.
【OBJECTIVE】Given the wide therapeutic properties of Goji berries, we aimed to evaluate whether supplementing the diet of lactating female rats with these could prevent the development of metabolic disorders in adult offspring raised in small litters.
【METHODS】Pregnant Wistar rats were used to prepare the litters. Two days after birth, male rats were divided into three groups: a normal litter (NL) with nine pups; a small litter (SL) of three pups; and a litter with three pups whose mothers were supplemented daily with 250 mg/kg of Goji berry extract during lactation (SLGB). All animals were monitored for 13 weeks postnatally.
【RESULTS】Maternal supplementation with Goji berry extract during lactation significantly decreased body weight gain, dyslipidemia, the atherogenic index, and the adiposity index. It also improved insulin resistance and glucose intolerance, presented a possible hypertrophic effect on skeletal muscle, and increased the uncoupling protein 1 (UCP-1) expression in the offspring in adulthood.
【CONCLUSIONS】Maternal supplementation with Goji berry extract had long-lasting effects and prevented the development of metabolic syndrome in the adult offspring that were overfed early in life.
相关物质
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