- 期刊Journal of agricultural and food chemistry（J Agric Food Chem）
- 发表时间2026-10-07
- 作者Li Y, Gao T, Wang Z, Wang M, Liang X, Gao W, Zhang X, Li M, Liang Z
- 卷期页码V74(39) : 30826-30844
- DOI10.1021/acs.jafc.6c08217
- PMID42915820
摘要机译
功能性低聚糖作为2型糖尿病（T2DM）的膳食干预已引起关注。然而，来自铁皮石斛（DOO1）的低聚糖在T2DM中的影响仍不清楚。本研究评估了DOO1对db/db小鼠代谢参数、肠道微生物群、短链脂肪酸（SCFAs）产生、肠道屏障功能和宿主代谢的影响。
DOO1显著改善了葡萄糖和脂质代谢紊乱，减少了胰腺和肝脏损伤。这些效果伴随着肠道微生物群组成的变化，其特征是邓卡尼氏菌、穆里杆菌和副杆菌的丰度增加，以及粪便SCFA水平升高。
DOO1改善了肠道屏障功能，如肠道通透性降低和炎症标志物（TNF-α、IL-1β、LPS）以及Muc2、ZO-1和Claudin-1的表达增加所示。DOO1还改变了宿主代谢谱，调节了肠道衍生激素和食欲相关神经肽。总的来说，这些发现表明DOO1可能通过调节肠道微生物群和宿主代谢来缓解T2DM相关代谢障碍。
展开英文摘要原文
Functional oligosaccharides have attracted attention as dietary interventions for type 2 diabetes mellitus (T2DM). However, the effects of oligosaccharides derived from Dendrobium officinale (DOO1) in T2DM remain unclear. This study evaluated the effects of DOO1 on metabolic parameters, gut microbiota, short-chain fatty acids (SCFAs) production, intestinal barrier function, and host metabolism in db/db mice. DOO1 significantly improved glucose and lipid metabolic disorders and reduced pancreatic and hepatic injury. These effects were accompanied by changes in gut microbiota composition, characterized by increased abundances of Duncaniella, Muribaculum, and Paramuribaculum, along with elevated fecal SCFA levels. DOO1 improved intestinal barrier function, as indicated by reduced intestinal permeability and inflammatory markers (TNF-α, IL-1β, LPS), and increased expression of Muc2, ZO-1, and Claudin-1. DOO1 also altered host metabolic profiles and regulated gut-derived hormones and appetite-related neuropeptides. Overall, these findings suggest that DOO1 may alleviate T2DM-related metabolic disorders by modulating gut microbiota and host metabolism.
相关物质
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