- 期刊Marine drugs（Mar Drugs）
- 发表时间2026-10-09
- 作者Zhang C, Qu Y, Xue L, Cheng B, Zang J
- 卷期页码V24(10)
- DOI10.3390/md24100354
- PMID42930483
摘要机译
本研究首次调查母猪从妊娠85天到泌乳21天日粮补充海带酶解物（KEH）的效果。24头长白×约克郡母猪被随机分配到4个处理：对照日粮（0%KEH）和3个添加0.75%、1.50%或3%KEH的实验日粮。
产后24 h背脂厚度随KEH的添加量呈线性增加（p=0.02），而活产仔猪数量呈二次响应（p=0.03）。KEH线性增加脐带血谷胱甘肽过氧化物酶活性（p=0.02），二次影响21日龄仔猪过氧化氢酶活性（p=0.02），在1.50%KEH时达到峰值。免疫球蛋白A（IgA；p=0.01）和M（IgM；
KEH使脐带血中P=0.02）呈二次性增强，峰值分别为1.50%和0.75%。KEH对7日龄仔猪血清IgG和21日龄仔猪IgM和IgG呈线性和二次性影响（p<0.05）。7日龄仔猪血清三碘甲原氨酸（p=0.03）和白细胞介素-1β（p<0.01）以及21日龄仔猪血清白细胞介素-6呈二次性反应（p<0.01）。
KEH对14日龄和21日龄仔猪白细胞介素-1β的影响呈线性和二次曲线（p<0.05）。母猪粪便乙酸浓度（p=0.09）和仔猪粪便异丁酸（p=0.06）和异戊酸（p=0.07）含量呈二次曲线趋势，而KEH对仔猪粪便戊酸浓度的影响呈二次曲线（p=0.02）。
肠道厚壁菌属和类杆菌属是优势门，乳酸杆菌属是母猪和仔猪的优势属。在仔猪中，霍尔德曼菌与几种短链脂肪酸呈正相关。
总体而言，妊娠后期和哺乳期膳食0.75-10.50%KEH改善了母猪及其后代的繁殖性能、免疫和抗氧化能力、炎症状态和肠道SCFAs谱。
展开英文摘要原文
This study is the first to investigate the effects of dietary supplementation with kelp enzymatic hydrolysate (KEH) from day 85 of gestation to day 21 of lactation in sows. Twenty-four Landrace × Yorkshire sows were randomly assigned to four treatments: a control diet (0% KEH) and three experimental diets supplemented with 0.75%, 1.50%, or 3% KEH. Backfat thickness at 24 h postpartum increased linearly with KEH supplementation (p = 0.02), while the number of piglets born alive showed a quadratic response (p = 0.03). KEH linearly increased glutathione peroxidase activity in umbilical cord blood (p = 0.02) and quadratically affected catalase activity in 21-day-old piglets (p = 0.02), which peaked at 1.50% KEH. Concentrations of immunoglobulin A (IgA; p = 0.01) and M (IgM; p = 0.02) in umbilical cord blood were quadratically enhanced by KEH, peaking at 1.50% and at 0.75% KEH, respectively. Serum IgG in 7-day-old piglets and IgM and IgG in 21-day-old piglets were linearly and quadratically influenced by KEH (p < 0.05). Quadratic responses were observed in serum triiodothyronine (p = 0.03) and interleukin-1β (p < 0.01) in 7-day-old piglets, as well as in serum interleukin-6 in 21-day-old piglets (p < 0.01). KEH had linear and quadratic effects in interleukin-1β in 14- and 21-day-old piglets (p < 0.05). Quadratic tendencies were detected in fecal acetic acid concentration in sows (p = 0.09) and in fecal isobutyric acid (p = 0.06) and isovaleric acid (p = 0.07) content in piglets, whereas the fecal valeric acid concentration in piglets was quadratically affected (p = 0.02) by KEH. Intestinal Firmicutes and Bacteroidota were the dominant phyla, with Lactobacillus being the most dominant genus in both sows and piglets. In piglets, Holdemanella was positively correlated with several short-chain fatty acids (SCFAs). Overall, dietary 0.75-1.50% KEH during late gestation and lactation improved reproductive performance, immune and antioxidant capacity, inflammatory status, and intestinal SCFAs profiles in both sows and their offspring.
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